According to a new report published
by Allied Market Research, titled, " Gene Therapy Market by Vector Type, Gene Type, and Application: Global
Opportunity Analysis and Industry Forecast, 2019–2026," the gene therapy market size was $393.35
million in 2018, and is estimated to reach $6,205.85 million by 2026,
registering a CAGR of 34.8% from 2019 to 2026.
Gene therapies are promising
therapies applicable to a broad range of diseases; their aim is to radically
treat the causes of the diseases instead of only relieving the symptoms. They
may be effective on a wide range of previously untreated diseases, such as
hematological, ocular, neurodegenerative diseases, and several cancers. For
example, adeno associated AAV2 vectors carrying the therapeutic gene (RPE65)
intra-retinal injection resulted in improved vision for people with Leber’s
Congenital Amaurosis. Gene therapies can be applied either in combination with
cell products and through an ex vivo treatment mode (e.g. Strimvelis), or
directly administered in vitro (e.g. Glybera). Several vectors present
clinically relevant options, including adenovirus (AV), adeno-associated virus
(AAV), and lentivirus.
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The increase in funding for R&D
activities pertaining to gene therapy and increase in awareness regarding gene
therapy are the major factors that drive the gene therapy market growth. In
addition, increase in government support, ethical acceptance of gene therapy
for cancer treatment, and rise in prevalence of cancer can fuel the growth of
the gene therapy market. However, high cost associated with the treatment and
unwanted immune responses are expected to hamper the growth of the gene therapy
market.
Among the vector type, non-viral
vector is anticipated to be a lucrative in the global gene therapy market, due
to the technological advancements such as physicochemical approaches that
includes material such as lipid, naked DNA, chromosomes, plasmid, cationic
polymers, and conjugate complexes of these vectors with positive results for
these therapies during the preclinical and clinical trials for the treatment of
various diseases.
Among the gene type, antigen
dominates the overall market accounting for two-ninths of the global gene
therapy market share in 2018. Among the applications, oncological disorders
segment is the largest contributor towards the growth of the gene therapy market,
owing to due to the availability of many gene therapy products that can be used
to treat cancer and large patient population base. In addition, there are large
number of gene therapies undergoing clinical trials for cancer and
cardiovascular diseases.
In 2018, North America accounted for
maximum contribution to the total revenue generated, and is anticipated to
continue this gene therapy market trends during the forecast period. This is
attributed to the high prevalence rate of cancer, presence of high disposable
income, and high funding for R&D activities associated with gene therapy.
However, Asia-Pacific is expected to witness the highest CAGR during the
forecast period owing to rise in incidence rate of cancer, increase in
government initiative to improve healthcare infrastructure, and rise in
healthcare expenditure.
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Key Findings of the Gene Therapy
Market :
- Non-viral vectors segment is projected to grow at the
highest rate with the CAGR of 34.6% during the analysis period.
- Oncological disorders segment generated the highest
revenue, and is expected to continue its dominance in future in the global
gene therapy market.
- Asia-Pacific is projected to grow at the fasted CAGR
during the forecast period.
- China is expected to grow highest in the Asia-Pacific
region during the forecast period.
- Tumor suppressor is the expected to grow fastest during
the forecast period.
The report provides a comprehensive
analysis of the key players operating in the global gene therapy market
industry, namely Adaptimmune Therapeutics Plc., Anchiano Therapeutics Ltd.,
Achieve Life Sciences, Inc., Adverum Biotechnologies, Inc., Abeona Therapeutics
Inc., Applied Genetic Technologies Corporation, Arbutus Biopharma Corporation,
Audentes Therapeutics, Inc., AveXis, Inc., Bluebird Bio, Inc., Celgene
Corporation, CRISPR Therapeutics AG, Editas Medicine, Inc., Editas Medicine,
Inc., GlaxoSmithKline Plc., Intellia Therapeutics, Inc., Merck & Co., Inc.,
Novartis AG, REGENXBIO Inc., Spark Therapeutics, Inc., Sangamo Therapeutics,
Inc., Uniqure N. V., Voyager Therapeutics, Inc.
Other prominent players in the value
chain (companies not profiled in the report) includes Amgen, Epeius
Biotechnologies, Sanofi, Juno Therapeutics, and Advantagene.
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